5,7,3',4'-Tetramethoxyflavone is an orally active polymethoxyflavone (PMF) isolated from M. exotica. It possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. It also exhibits chondroprotective activity by targeting β-catenin signaling.
- Possesses anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory properties.
- Exhibits chondroprotective activity by targeting β-catenin signaling.
- Protects chondrocytes from ER stress-induced apoptosis.
- Decreases inflammatory cytokines.
- Inhibits chondrocyte hypertrophy.